My research interests generally lie in the
area of immune function as it is affected by physical activity and nutritional
status. Much of my recent work has focused on the effects of various
modes (running, cycling, rowing) of high-intensity, long duration exercise
on stress hormones and their suppressive effects on immune function.
Particular emphasis has focused on the beneficial influence of carbohydrate
beverage ingestion during the exercise. In previous studies with
runners and cyclers, we have shown that carbohydrate ingestion attenuates
the stress hormone response and this in turn, has an effect on diminishing
immunosuppression. Whether these effects positively influence the
incidence of infection in athletes following exercise remains to be established.
Other interests include the analysis of immune function in individuals
of various nutritional status, including obesity and anorexia nervosa.
Upcoming Projects
Influence
of Carbohydrate Ingestion on Immune Function and Infection in Charlotte
Marathon Runners (SPRING 1999)
This study will be conducted on 50 runners
participating in the Charlotte Marathon on April 10, 1999. The study
will look at the effects of carbohydrate ingestion on immune function and
stress hormone responses as they relate to the incidence of upper respiratory
tract infections two weeks prior and two weeks following the race.
The project is being conducted in collaboration with Dr. David Nieman of
the Department of Health, Leisure, and Exercise Science at Appalachian
State and Dr. Gerald Sonnenfeld of the Department of Immunology Research
at The Carolinas Medical Center in Charlotte, NC. The study will
be continued on an additional 50 runners participating in the Charlotte
Marathon in April, 2000.
Acute
and Chronic Immune Responses to Tennis Competition (SPRING 1999)
This study will be conducted on 20 elite tennis
athletes and 20 age-matched nonathletes (ages 13-17 years). The athletes
will be in training at the Van Der Meer World Class Tennis Training Center
in Hilton Head, SC. The study will 1) compare the resting immune
function in the two groups, 2) investigate the influence of carbohydrate
ingestion on immune and hormonal responses to 2 hours of high-intensity
tennis competition in the elite tennis players and, 3) relate the immune
parameters to upper respiratory tract infection history to establish a
simple marker that identifies athletes at risk. The project is being
conducted in collaboration with Dr. David Nieman of the Department of Health,
Leisure, and Exercise Science at Appalachian State and Dr. Gerald Sonnenfeld
of the Department of Immunology Research at The Carolinas Medical Center
in Charlotte, NC.