Karatan Lab




Ece Karatan

Appalachian State University
Department of Biology
Rankin Science North
319 (Office), 303 (Lab)


Karatan Lab is located in the Department of Biology at Appalachian State University. The main focus of the reseach in our lab is biofilm formation in Vibrio cholerae.

karatan lab 2014-2015

Karatan lab 2014-2015. Left to right: Ece Karatan, Richard Sobe, Marybeth Burriss, Alex Mozina, Libby Villa, Will Brennan, Blake Sanders

We are always looking for enthusiastic graduate and undergraduate students to join the lab. Funding for a Master's degree is available to graduate students in the form of teaching assistantships and various fellowships.In addition, opportunities may be available for undergraduate students to do research in the lab for independent study credit or credit towards the University and/or Departmental Honors program. If you are interested in joining the Karatan Lab please contact Ece Karatan.

Lab News:

March 2014: Randy and Alex's first co-author NspS paper gets accepted into Microbiology.

January 2014: Josiah starts his postdoc as a Reseach Fellow at NASA Ames Research Center, Space Bioengineering Branch

December 2013: Nick gets accepted into medical school at Virginia Commonwealth University.

November 2013: Brad gets accepted into the School of Osteopathic Medicine at Campbell University.

Aprl 2012: Brad and Nick's polyamine effects on V. cholerae virulence properties paper gets published in PLOS ONE.

April 2012: Brad gets accepted into the post-baccalaureate program in biomedical sciences at Edward Via Virginia College of Osteopathic Medicine

March 2012 : Alex gets accepted into the PhD program in Biomedical Sciences at Medical University of South Carolina

February 2012: Sam gets accepted into the PhD program in Molecular and Cellular Biosciences at Wake Forest University


Previous years' lab members:

Selected publications:

Vibrio cholerae NspS, a homologue of ABC-type periplasmic solute binding proteins, facilitates transduction of polyamine signals independent of their transport. Cockerell, SR., Rutkovsky, AC., Zayner, JP., Cooper, RE., Porter, LR., Perndergraft, SS., Parker, ZM., McGinnis, MW., and Karatan, E. (2014) Microbiology 160 (Pt 5): 832-43

Effects of polyamines on Vibrio cholerae virulence properties. Goforth, JB, Walter, NE, and Karatan, E. (2013) PLoS One. 8(4):e60765

Elevated levels of the norspermidine synthesis enzyme NspC enhance Vibrio cholerae biofilm formation without affecting intracellular norspermidine concentrations. Parker, ZM., Pendergraft, SS., Sobieraj, L., McGinnis, M., and Karatan, E. (2012) FEMS Microbiol Lett 329 (1):18-27

Increased abundance of Gallionella spp., Leptothrix spp., and total bacteria in response to enhanced Mn and Fe concentrations in a disturbed southern Appalachian high elevation wetland.  Johnson, KW., McDonald, W., Carmichael, MJ., Pitchford, J., Windelspecht, M., Karatan, E.., and Brauer, SL. (2012) Geomicrobiology Journal 29 (2):124-138

Spermidine regulates Vibrio cholerae biofilm formation via transport and signaling pathways. McGinnis MW, Parker ZM, Walter NE, Rutkovsky AC, Cartaya-Marin C, Karatan E. (2009) FEMS Microbiol Lett 299(2):166-74.

Signals, regulatory networks, and materials that build and break bacterial biofilms. Karatan E., Watnick, PI. (2009) Microbiol Mol Biol Rev 73: 310-347.

NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine. Karatan E., Duncan, T., Watnick PI. (2005) J Bacteriol 187: 7434-7443.

Biofilm Development in Bacteria. Kierek-Pearson K. and Karatan E. (2005). In: Advances in Applied Microbiology, Laskin, AI., Bennett, JW., and Gadd, MG. (Ed) Elsevier Inc.  Vol. 57 pp. 79-112

Role for glycine betaine transport in Vibrio cholerae osmoadaptation and biofilm formation within microbial communitiesKapfhammer D., Karatan E., Pflughoeft K.J., Watnick P.I. (2005) Appl. Environ. Microbiol. Jul; 71(7):3840-7.

Antibody Arrays Prepared by Cutinase-Mediated Immobilization on Self-Assembled Monolayers. Kwon Y., Han Z., Karatan E., Mrksich M., Kay B.K. (2004) Anal. Chem. Oct 1;76(19):5713-20.

Molecular Recognition Properties of FN3 Monobodies that Bind the Src SH3 Domain. Karatan E., Merguerian M., Han Z., Scholle MD., Koide S., Kay BK. (2004) Chem. Biol. Jun;11(6):835-44

Accelerated Screening of Phage-Display Output with Alkaline Phosphatase Fusions. Han Z., Karatan E., Scholle MD., McCafferty J., Kay BK. (2004) Comb. Chem. High Throughput Screen. Feb; 7 (1): 55-62

Effect of Loss of CheC and Other Adaptational Proteins on Chemotactic Behaviour in Bacillus subtilis. Saulmon MM., Karatan E., Ordal GW. (2004) Microbiology; (150): 581-589