Publications - Research Interests - Teaching
Dr. Annkatrin Rose
| Assistant Professor, Plant Molecular Biology |
Ph.D. University of Hamburg, Germany Postdoc Dr. Iris Meier's Lab, The Ohio State University |
|
| Department of Biology Appalachian State University PO Box 32027 Boone, NC 28608-2027 Phone: (828) 262-7395 - |
Office Hours (Rankin Science West 266) for Fall Semester 2009:
- Tuesday, Thursday, 11:00 AM - 12:00 PM
- Wednesday, Friday, 11:00 AM - 1:00 PM
- Tuesday, 4:00 PM - 5:00 PM
- Other times by appointment if my regular office hours conflict with your schedule
Publications
Rose, A. (2009) Nuclear pores in plant cells: structure, composition, and functions. In: Meier, I. (ed.), Functional Organization of the Plant Nucleus, Springer-Verlag, Heidelberg, 2008. Plant Cell Monogr. 14: 29-53.
Xu, X., Rose, A., and Meier, I. (2007). NUA activities at the plant nuclear pore. Plant Signaling and Behavior 2: 553-555.
Xu, X., Rose, A., Muthuswamy, S., Jeong, S.Y., Venkatakrishnan, S., and Meier, I. (2007). NUCLEAR-PORE ANCHOR, the Arabidopsis homolog of Tpr/Mlp1/Mlp2/Megator, is involved in mRNA export, SUMO homeostasis and the regulation of flowering time via FLOWERING LOCUS C. Plant Cell 19: 1537-1548.
Merchant et al. (2007) - 87th author of 117. The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science 318: 245-250.
Rose, A. (2007) Open mitosis: nuclear envelope dynamics. In: Verma, D.P.S., and Hong, Z. (eds.), Cell Division Control in Plants, Springer-Verlag, Heidelberg. Plant Cell Monogr. 9: 207-230.
Rose, A., Stahlberg, E.A., and Meier, I. (2007) Genome-wide identification and comparative analysis of coiled-coil proteins. Scalable Computing: Practice and Experience 8: 167-171.
Rose, A., Schraegle, S.J., Stahlberg, E.A., and Meier, I. (2005). Coiled-coil protein composition of 22 proteomes - differences and common themes in subcellular infrastructure and traffic control.
BMC
Evolutionary Biology 5:66.
Patel, S., Brkljacic, J., Gindullis, F., Rose, A., and Meier, I. (2005).
The plant nuclear envelope protein MAF1 has an additional location at the Golgi and
binds to a novel Golgi-associated coiled-coil protein.
Planta 222,1028-1040.
Jeong, S. Y., Rose, A., Joseph, J., Dasso, M., and Meier, I.
(2005). Plant-specific mitotic targeting of RanGAP requires a functional WPP
domain.
Plant Journal 42, 270-282.
Patel, S., Rose, A., Meulia, T, Dixit, R., Cyr, R. J., and Meier, I.
(2004). Arabidopsis WPP-domain proteins are developmentally associated with the
nuclear envelope and promote cell division.
Plant Cell 16, 3260-3273.
Rose, A., Patel, S., and Meier, I. (2004). Plant
nuclear envelope proteins.
In: Evans, D. E.,
Hutchinson, C. J., Bryant, J. A. (eds), The Nuclear Envelope.
Garland/Bios Scientific Publishers, Abingdon. ISBN 0-4153-4645-2
Symposium of the Society for
Experimental Biology 56, 69-88.
Rose, A., and Meier, I. (2004) Scaffolds, levers, rods, and
springs: Diverse cellular functions of long coiled-coil proteins.
Cellular and Molecular Life Sciences 61, 1996-2009.
Rose, A., Manikantan, S., Schraegle, S., Maloy, M., Stahlberg, E., and Meier, I.
(2004). Genome-wide identification of Arabidopsis coiled-coil proteins and establishment of the
ARABI-COIL database.
Plant
Physiology 134, 927-939.
Rose, A., Patel, S., and Meier, I. (2004). The plant nuclear envelope.
Planta 218, 327-336. (published online Nov. 2003)
Jeong, S. Y., Rose, A., and Meier, I. (2003).
MFP1 is a thylakoid-associated, nucleoid-binding protein with a coiled-coil structure.
Nucleic Acids Research 31, 5175-5185.
Rose, A., Gindullis, F., and Meier, I. (2003).
A novel alpha-helical protein, specific to and highly conserved in plants, is associated with the nuclear
matrix fraction.
Journal of Experimental Botany 54, 1133-1141.
Gindullis, F., Rose, A., Patel, S., and Meier, I. (2002).
Four signature motifs define the first class of structurally related large coiled-coil proteins in plants.
BMC Genomics 3:9.
Rose, A. and Meier, I. (2001).
A domain unique to plant RanGAP is responsible for its targeting to the plant nuclear rim.
Proceedings of the National Academy of Sciences U.S.A. 98, 15377-15382.
Rose, A., Meier, I., Wienand, U. (1999).
The tomato I-box binding factor LeMYBI is a member of a novel class of Myb-like proteins.
Plant Journal 20, 641-652.
Research Interests
I am interested in a group of plant proteins characterized by a "coiled-coil" structural motif. Coiled-coil proteins are typically involved in forming fibers and scaffolds in cells and help organize the shape, substructures, and movement of organelles within cells. In humans, mutations in coiled-coil proteins have been implemented in diseases such as cancer, muscular dystrophy, premature aging, and neurological defects. I am studying this group of proteins in plants to understand their role in an organism that does not possess muscle or nerve cells (where most long coiled-coil structures are found and studied in animals).
The group of proteins that I am particularly interested in is the chloroplast coiled-coil proteins. Chloroplasts are photosynthetic organelles that are thought to have evolved from endosymbiotic prokaryotes. However, most prokaryotes do not contain long coiled-coil proteins of the type we find in eukaryotic cells. Therefore, their import into chloroplasts is intriguing and suggests that they may have played a crucial role in the evolution of early endosymbionts into the highly structured photosynthetic organelles we find today. The study of these proteins should provide further insight into chloroplast structure and function as well as the relationship between the organelle and the host cell.
Fig. 1: Localization of the coiled-coil protein MFP fused to Green Fluorescent Protein in a living Arabidopsis protoplast (top) and co-localization with free chloroplasts (bottom).
Teaching (at ASU)
| Spring 2010 | BIO2000-202 - Botany Lab - Tue., 9:30 - 12:20 PM BIO2400-101 - Genetics Lecture - Mon., Wed., 1:00 - 2:15 PM BIO2400-102 - Genetics Lecture - Tue., Thu., 3:30 - 4:50 PM Graduate Level: |
| Fall 2009 |
BIO2000-204 - Botany Lab - Wed., 1:00 - 3:50 PM Graduate Level: |
| Spring 2009 | BIO2000-202 - Botany Lab - Tue., 2:00 - 4:50 PM BIO2000-204 - Botany Lab - Thu., 10:00 - 12:50 PM Graduate Level: |
| Fall 2008 | BIO2000-101 - Botany Lecture - Mon., Wed., Fri., 12:00 - 12:50 PM BIO2000-201 - Botany Lab - Tue., 9:30 AM - 12:20 PM BIO2000-202 - Botany Lab - Tue., 2:00 - 4:50 PM Graduate Level: |
| Spring 2008 | BIO2000-202 - Botany Lab - Tue., 2:00 - 4:50 PM BIO3306-101 - Genetics Lecture - Mon., Wed., Fri., 1:00 - 1:50 PM Graduate Level: |
| Fall 2007 | BIO2000-202 - Botany Lab - Tue., 9:30 AM - 12:20 PM Graduate Level: |
| Spring 2007 | BIO2000-203 - Botany Lab - Wed., 12:00 - 2:50 PM BIO2000-204 - Botany Lab - Thu., 10:00 - 12:50 PM |
| Fall 2006 | BIO2000-203 - Botany Lab - Wed., 12:00 - 2:50 PM BIO2000-205 - Botany Lab - Thu., 1:00 - 3:50 PM Graduate Level: |